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Duggan
Veterinary Supplies
Holycross
Thurles
Co Tipperary
Rep of Ireland
W:+353 (0)504 43169
FAX:+353 (0) 504 43147
E-mail:
info@dugganvet.ie
Drontal
Plus for Dogs |
|
| PRODUCTS / COMPANION ANIMAL MEDICINE \ DRONTAL PLUS FOR DOGS | |
| Active |
Ingredient Febantel, Praziquantel, Pyrantel embonate |
| Category | Endoparasiticides |
| Target | Specificity Dog |
| Mode of Action |  Praziquantel:
Praziquantel kills mature and immature development stages of tapeworms
in the intestine after a single treatment. Within a few seconds of
the tapeworm coming into contact with praziquantel its interaction
with phospholipids and proteins causes damage to the tegument. The
inflow of Ca+2Ions results in an immadiate contraction of the entire
strobila. Moreover, these changes lead to a reduction of glucose intake
and an accelerated depletion of energy reserves. Pyrantel embonate:
Pyrantel, an anthelmintic of the tetrahydropyrimidine group of compounds,
acts in a similar way to levamisol, by inducing a depolarising neuromuscular
blockade. Pyrantel, being a cholinergic agonist, acts as an excitatory
neurotransmitter at the nicotinergic receptor causing spastic pralysis
of the parasite. Febantel: The mechanism of action of febantel is
primarily based on interference with the carbohydrate metabolism of
the worm. The suppression of mitochondrial reactions (inhibition of
fumarate reductase) and interferencewith glucose transport act not
only on all developmental stages of the helminths but also on the
eggs containing the larvae. Benzimidazoles bind to the structural
protein tubulin, thereby preventing its polymerization to microtubules
which provide the transport system for the absorbing cells. The consequence
of blocking this transport activity is incomplete absorption and digestion
of nutrient particles and cellular autolysis through activation of
lysosomal enzymes. |
| Indication/Description | DRONTAL PLUS possesses an extremely wide spectrum of activity. Its uses cover infestation with the following dog roundworms and tapeworms: Roundworms: - Toxocara canis - Toxascaris leonina Hookworms: - Uncinaria stenocephala - Ancylostoma caninum Tapeworms: - Echinococcus granulosus - Echinococcus multilocularis - Dipylidium caninum - Taenia spp. - Multiceps multiceps - Mesocestoides spp. |
| CAS No | Praziquantel:55268-74-1 Pyrantel embonate:22204-24-6 Febantel: 58306-30-2) |
| Chemical Name | Praziquantel: 2-(cyclohexylcarbonyl)-1,2,3,6,7,11b-hexahydro-4H-pyrazino(2,1-a)isoquinolin- 4-one Pyrantel embonate: (E)-1,4,5,6-tetrahydro-1-methyl-2-[2-(2-thienyl)ethenyl]pyrimidine and 4,4'-methylenebis[3-hydroxy-2-naphthalenecarboxylic acid (1:1) Febantel:Dimethyl-[2-[(methoxyacetyl)amino]-4-(phenylthio)phenyl]carbonimidoyl] biscarbamate Praziquantel: |
| Dosage | 1 TABLET PER 10KG |