STARTVAC- A TECHNICAL OVERVIEW

STARTVAC

Inactivated vaccine against bovine mastitisCOMPOSITION PER MLOne dose (2 ml) contains:

E. coli J5 inactivated >50 RED60*, S. aureus CP8 inactivated strain

SP140 expressing SAAC >50RED

80. *(Slime Associated Antigen Complex (SAAC)). * RED: Rabbit

effective dose in 60% or 80% of animals (serology).Liquid paraffin: 18.2 mg. Benzyl alcohol: 20 mg.INDICATIONSFor the immunization of dairy cows in stables with recurring problems of mastitis, to reduce the incidence of sub-clinical mastitis and the incidence and severity of clinical signs of mastitis caused by

Staphylococcus aureus, coagulase-negative staphylococci and coliforms.

The complete schedule of immunization induces immunity from approximately 13 days after the first injection until about 78 days after the third injection (equivalent to 130 days after calving).DOSOGE AND METHOD OF ADMINISTRATION

Intramuscular use. It is preferable that the injections be administered on alternate sides of the neck. Administer one dose (2 ml) by deep intramuscular injection into the neck muscles according to the following indications:

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- First injection at 45 days before the expected date of parturition.

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- Second injection 35 days afterwards (10 days before the expected date of parturition).

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- Third injection 62 days after the second injection (corresponding to 52 days after

parturition).The complete immunization programme should be repeated in each pregnancy.CONTRAINDICATIONS AND ADVERSE REACTIONSNo contraindications.Temporary slight to moderate local reactions may occur after a dose of the vaccine is administered.They mainly include: swelling (up to 5 cm2 on average), which vanish one or two weeks later at most. In some cases, pain may also appear at the inoculation site that spontaneously subsides by 4 days later at most.There may be a transient increase in body temperature of about +1 °C and up to +2 °C in somecows in the first 24 hours after injection. Animals immunized with an overdose showed no adverse reactions other than those observed after administration of a single dose of the vaccine.If you notice any serious effects or any other not listed in this leaflet, please report it to your

veterinarian.

WITHDRAWAL PERIODZero days.SPECIAL PRECAUTIONS FOR STORAGEKeep out of reach and sight of children.Store and transport refrigerated (+2 °C to +8 ºC) and protected from light.Do not freeze.Do not use after the expiration date on the label.Shelf life after opening the immediate packaging of the drug: 10 hours when kept between +15 ºCand +25 ºC.SPECIAL WARNING(S)The entire stable must be immunizedImmunization should be considered as a component in a complete program of mastitis control thataddresses all important health factors of the udder (e.g., milking technique, drying andreproduction management, hygiene, nutrition, housing, bedding, comfort of the cow, air and water

quality, monitoring of health) and other management practices.

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